@article{NCRI3795,
author = {Katrine Mandrup Nielsen and Thomas Birkballe Hansen},
title = {CircCCDC66: the colorectal oncogene},
journal = {Non-coding RNA Investigation},
volume = {1},
number = {2},
year = {2017},
keywords = {},
abstract = {Circular RNAs (circRNAs) are a large class of long non-coding RNAs produced by backsplicing or “head-to-tail” splicing (1). Due to the lack of free ends, circRNAs escape the conventional exonucleolytic RNA degradation pathways and thus have much higher stability than linear RNAs. The high stability allows the circRNAs to accumulate to high levels and conduct functions for prolonged periods in cells (2-4). Specific circRNAs have been functionally characterized as protein sponges, miRNA sponges, protein scaffolds or regulators of splicing and transcription (5-7). Many circRNAs are differentially expressed in cancerous tissues correlating with cancer progression (8,9). Among these, the circRNAs circFOXO3 and circITHC have been identified as tumor-suppressor circRNAs that are downregulated in tumor tissues. For both circRNAs, it has been suggested that they function as miRNA sponges to protect tumor-suppressor genes from miRNA attack (10,11) (Figure 1). However, the function of most circRNAs remains elusive although many of them have a high potential as biomarkers in cancer.},
issn = {2522-6673}, url = {https://ncri.amegroups.org/article/view/3795}
}