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Exosomal miR-34a: the code for adipocyte-macrophage communication

   
@article{NCRI5156,
	author = {Xiao Han and Yaqin Zhang},
	title = {Exosomal miR-34a: the code for adipocyte-macrophage communication},
	journal = {Non-coding RNA Investigation},
	volume = {3},
	number = {0},
	year = {2019},
	keywords = {},
	abstract = {The study “Adipocyte-secreted exosomal microRNA-34a inhibits M2 macrophage polarization to promote obesity-induced adipose inflammation”, presented by Pan et al. and published in J Clin Invest, has been read by us with great interest (1). In this study, the authors uncovered adipocyte-secreted exosomes as a potentially novel mediator of obesity-induced adipose inflammation, acting by transporting miR-34a into the adjacent macrophages, where it drives the polarization program toward proinflammatory M1 phenotype by targeting the transcription factor KLF4. Indeed, this study provided a new question for obesity-induced systemic inflammation and metabolic dysregulation, but in terms of the molecular mechanism of miR-34a on M1/M2 polarization, there still are something to clarify and need for more investigation.},
	issn = {2522-6673},	url = {https://ncri.amegroups.org/article/view/5156}
}