Association of miR-223 expression with myocardial ischemia/reperfusion injury: new insight for the role of miR-223 in inflammatory response

Early reperfusion strategy is the most effective therapy to improve survival rates in patients suffering acute myocardial infarction (1). However, reperfusion therapy always results in myocardial ischemia reperfusion injury (I/RI) and patients are at risk of developing heart failure (2). Cardiac remodeling is a progression which is linked to heart failure and is associated with poor prognosis clinically.