Functional relevance of pyknons in tumor formation

In a recent Genome Biology paper, Rigoutsos et al. describe the functional characterization of a novel, pyknon- containing RNA. Their highly cooperative and pioneering work in pyknon and long non-coding RNA (lncRNA) research (1) indicates the role of the novel pyk-reg-90- containing lncRNA, novel pyk-reg-90-containing lncRNA (N-BLR), in cellular and molecular physiology as well as in the proliferation and metastasis-formation capabilities of colorectal cancer (CRC) cells. Well-grounded in silico, in vitro and in situ results are supported by patient survival data.